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Studies on the Specific Degranulation of Mast Cell Sensitized by Several Allergens in vitro

Food allergy is a major health issue worldwide. Mast cells play a very important role in the immediate hypersensitivity for which mast cell degranulation needs to be studied extensively. In this study, an approach was taken to study the characteristics of sensitized mast cell degranulation in vitro, which associated with the study of mast cells and animal models. BALB/c mice were immunized respectively by several food allergens, then blood and peritoneal mast cells were collected at different time points. A dynamic determination was carried out between mast cells and serumal IgE. Comparative analysis on sequential time points showed that there was a close coincidence between mast cell degranulation and IgE antibody titers in sensitized BALB/c mice. Furthermore, it is interesting that sensitized mast cells could implement specific degranulation against the challenges in vitro, but the closely tropomyosins induced mast cell degranulation displayed cross reactions. This is very similar to IgE resisting the allergens in vivo. The study disclosed some characteristics on mast cells, coming from sensitized BALB/c mice, degranulation in vitro.

Haider Samee Jamil Khalid
Food safety laboratory, Ocean University of China Pakistan Council for Scientific and Industrial Research Laboratories Complex
supported by National High Technology Research and Development Program of China (863 Program) (NO.2006AA09Z427) Nature Science Foundation of China (No. 30800859 and No. 30871948)
R593
《Cellular & Molecular Immunology》 2009年第02期149-153页
《Cellular & Molecular Immunology》2009年第02期文献

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