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Acute Morphine Administration Reduces Cell-Mediated Immunity and Induces Reactivation of Latent Herpes Simplex Virus Type 1 in BALB/c Mice

Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte (CTL) activity in the inhibition of herpes simplex virus type 1 (HSV-1) reactivation, the effect of acute morphine administration on CTL responses was also evaluated. Furthermore, lymphocyte proliferation and IFN-γ production were evaluated for their roles in the induction of the CTL response. The findings showed that acute morphine administration significantly reduced CTL responses, lymphocyte proliferation, and IFN-γ production. Furthermore, acute morphine administration has been shown to reactivate latent HSV-1. Previous studies have shown that cellular immune responses have important roles in the inhibition of HSV reactivation. These findings suggest that suppression of a portion of the cellular immune response after acute morphine administration may constitute one part of the mechanism that induces HSV reactivation.

Shafi Mojadadi Abbas Jamali Behzad Khansarine jad Hoorieh Soleimanjahi Taravat Bamdad
Neuroscience research center, Kerman University of Medical Sciences Department of Virology, Faculty of medical science, Tarbiat Modares University Dept of virology, School of medicalsciences, Tarbiat Modares University Dept of Microbiology, Arak University of Medical Sciences
supported by the Neuroscience research center, Kerman University of Medical Sciences.
R-332
《Cellular & Molecular Immunology》 2009年第02期111-116页
《Cellular & Molecular Immunology》2009年第02期文献
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